Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ Pubmed: 37938974 DOI: doi:10.1016/j.celrep.2023.113366 ]
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ Pubmed: 37938974 DOI: doi:10.1016/j.celrep.2023.113366 ]
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EBOV GP in complex with IgG c2G4 and c13C6 Fabs
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5kel
Q-score: 0.309
Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB
Nat Microbiol (2016) 1 pp. 16128-16128 [ Pubmed: 27562261 DOI: doi:10.1038/nmicrobiol.2016.128 ]
- C2g4 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- C13c6 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- C2g4 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- Ebola surface glycoprotein, gp2 (16 kDa, Protein from Zaire ebolavirus)
- Ebola virus trimeric surface glycoprotein in complex with igg c2g4 and c13c6 fabs (540 kDa, Complex from Zaire ebolavirus)
- Ebola surface glycoprotein, gp1 (50 kDa, Protein from Zaire ebolavirus (strain Mayinga-76))
- C13c6 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EBOV GP in complex with IgG c4G7 and c13C6 Fabs
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5ken
Q-score: 0.185
Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB
Nat Microbiol (2016) 1 pp. 16128-16128 [ Pubmed: 27562261 DOI: doi:10.1038/nmicrobiol.2016.128 ]
- C4g7 variable fab domain heavy chain (12 kDa, Protein from Homo sapiens)
- C13c6 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- C4g7 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- Ebola surface glycoprotein, gp2 (12 kDa, Protein from Zaire ebolavirus (strain Mayinga-76))
- C13c6 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- Ebola virus trimeric surface glycoprotein in complex with igg c4g7 and c13c6 fabs (540 kDa, Complex)
- Ebola surface glycoprotein, gp1 (30 kDa, Protein from Zaire ebolavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)